Publications

Made Possible with Christini Fund Support

Dr. Naviaux

 

Robert K. Naviaux, MD, PhD  
UC San Diego School of Medicine
The Mitochondrial and Metabolic Disease Center

 

 

  1. Naviaux RK, Nasirian F, Barshop BA, Nyhan WL, Haas RH (1996). The role of reverse transcription in the replication of mitochondrial DNA (Abstract). Annual meeting of the Society for Inherited Metabolic Disorders.

  2. Naviaux RK, Barshop BA, Nyhan WL, Haas RH. (1996). Reverse transcription and the bipotential replication of mitochondrial DNA (Abstract). Annals of Neurology 40:293.

  3. Naviaux RK, Nasirian, F, Longenecker AM, Shelton D, Barshop BA,Nyhan WL, Haas RH. DNA polymerase gamma deficiency in mitochondrial disease (Abstract). Annals of Neurology 40:39, 1996.

  4. Naviaux RK, Barshop BA, Nyhan WL, Haas RH (1996). Pararetrovirus-like replication of mitochondrial DNA (Abstract). Cold Spring Harbor Retrovirus Meeting, May 21-26.

  5. Naviaux RK. The mitochondrial DNA depletion syndromes: mitochondrial DNA polymerase deficiency, in Atlas of Metabolic Diseases, Nyhan WL (ed), Chapman & Hall, London, pp. 314-320, 1998.

  6. Naviaux RK, Barshop BA, Poulton J, Nyhan WL, Haas RH. Mitochondrial DNA polymerase g deficiency and mitochondrial DNA depletion in a child with Alpers Syndrome. Annals of Neurology 1999; 45:54-58.

  7. Naviaux RK, Markusic D, Barshop BA, Nyhan WL, Haas RH. Sensitive assay for mitochondrial DNA polymerase g. Clinical Chemistry 45:1725-1733, 1999.

  8. Barshop BA, Nyhan WL, Naviaux RK, McGowan KA, Friedlander M, and Haas RH. Kearns-Sayre syndrome presenting as 2-oxoadipic aciduria. Molecular Genetics and Metabolism 69: 64-68, 2000.

  9. Naviaux RK. Adult presentations of mitochondrial disease. United Mitochondrial Disease Foundation Newsletter, 5(March):1-14, 2000.

  10. Naviaux RK, McGowan KA. 2000. Organismal effects of mitochondrial dysfunction. Human Reproduction 15(Suppl 2):44-56.

  11. Naviaux RK. 2000. Mitochondrial DNA Disorders. European J Pediatrics 159:S219-S226.

  12. Graf WD, Marin-Garcia J, Gao HG, Pizzo S, Naviaux RK, Markusic D, Barshop BA, Courchesne E, Haas RH. Autism associated with the mtDNA G8363A tRNA lysine mutation. J Child Neurol 2000;15:357-361.

  13. Naviaux RK. Options and challenges in the treatment of mitochondrial disease. Genetics and Medicine 2:56, 2000.

  14. Naviaux RK, Nyhan WL. Galactosemia, in Cecil’s Textbook of Medicine, 21st edition, 2000, pp1084-1086.

  15. Naviaux RK. The State of Mitochondrial Medicine 2000—Report to the United Mitochondrial Disease Foundation. Sept 20, 2000.

  16. Spruijt L, Naviaux RK, McGowan KA, Nyhan WL, Sheean G, Haas RH, Barshop BA. Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. Muscle and Nerve 24:916-924, 2001.

  17. Scaglia F, Sutton VR, Vogel H, Naviaux RK, Vladutiu G, Bodamer AF, Shapira S. Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria. J Child Neurol 16(2):136-138, 2001.

  18. Bodman M, Smith D, Nyhan WL, Naviaux RK. Medium-chain acyl coenzyme A dehydrogenase deficiency: occurrence in an infant and his father. Archives of Neurology 58(5):811-814, 2001.

  19. Naviaux RK. 2001. The coding problem—why no one can die of mitochondrial disease in America. Mitochondrion 1:99 (A34), 2001.

  20. Naviaux RK. 2001. Is animal cell mitochondrial DNA the relic of a Precambrian phage? A Protovirus hypothesis. Mitochondrion 1:108 (A58), 2001.

  21. Naviaux RK, McGowan KA, Barshop BA, Nyhan WL, Haas RH. Correction of renal tubular acidosis in mitochondrial disease patients treated with triacetyluridine (PN401). Society for Inherited Metabolic Disorders, Annual Meeting, March 12-15, 1999.

  22. Naviaux RK, Tarek Hassanein, Asim Guha Roy, Cynthia Behling, Marc R. Garfinkel, Andrew Precht, Vijay Pinto, Kenneth Martinez, Rhonwyn L. Curtis. Late Onset, Subacute, Fulminant Hepatic Failure, Renal Failure, and Coma Resulting from Valproic Acid Treatment and Intercurrent Infection in an Adult with Mitochondrial Disease. Mitochondrion 1:88 (A4), 2001.

  23. Le T, Kwon G-C, Barshop BA, Naviaux RK. A sensitive assay of dihydroorotate CoQ oxidoreductase using mass spectrometry. Mitochondrion 1:92 (A14), 2001.

  24. Naviaux RK. De Novo Pyrimidine Biosynthesis is Coupled to Mitochondrial Oxidative Phosphorylation via the Inner Mitochondrial Membrane Protein Dihydroorotate CoQ Oxidoreductase (DHO-QO). DARPA/NASA Photobiology Workshop, 2nd International NOA Conference 2001. Center for Advanced Space Sciences (CASS), Houston, TX, 5/31-6/1/01.

  25. Naviaux RK. Assay of mitochondrial DNA polymerase g from human tissues, in Copeland W (ed) Methods in Molecular Biology, vol 197, Mitochondrial DNA: Methods and Protocols, Humana Press Inc., Totowa, NJ, pp. 259-271, 2002.

  26. Naviaux RK, Singh KK. Ooplasmic transfer and the mitochondrial germ line. Nature 413:347, 2001.

  27. Edmonds J, Kirse DJ, Kearns D. Deutsch R, Spruijt L, Naviaux RK. The otolaryngological manifestations of mitochondrial disease and the risk of neurodegeneration with infection. Arch. Otolaryngol Head Neck Surg 128:355-362, 2002.

  28. Naviaux RK. Mitochondrial Metabolism and the Injured Cell Response to Near-Infrared Light. Joint Conference, Defense Advanced Research Projects Agency (DARPA) and 2nd Congress of the North American Association for Laser Therapy (NAALT), Atlanta, GA, March 5-8, 2002.

  29. Nyhan W, Khanna A, Barshop B, Naviaux RK, Precht A, Lavine J, Hart M, Hainline B, Wappner R, Nichols S, Haas RH. Pyruvate carboxylase deficiency-insights from liver transplantation. Mol Genet Metab. 77(1-2):143-146, 2002.

  30. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas RH, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 59(10):1541-1550, 2002.

  31. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, Vladutiu GD, England JD. Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 137(7):581-585, 2002.

  32. Petit C, Mathez D, Barthelemy C, Leste-Lasserre T, Naviaux RK, Sonigo P, Leibowitch J. Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion. J Acquir Immune Defic Syndr 33(4):461-469, 2003.

  33. Naviaux RK. The Spectrum of Mitochondrial Disease, in Mitochondrial and Metabolic Disorders: A Primary Care Physician’s Guide, 2nd ed. 2003.

  34. Naviaux RK. Mitochondrial mechanisms of light-stimulated tissue regeneration. ECI/NAALT Conference, Kona, Hawaii, August 2-27, 2004.

  35. McGowan KA, Nyhan WL, Barshop BA, Naviaux RK. The role of methionine in ethylmalonic encephalopathy with petechiae. Arch Neurol. 61:570-574, 2004.

  36. Naviaux RK, Nguyen KV. POLG mutations associated with Alpers’ syndrome and mitochondrial DNA depletion. Ann Neurol. 55:706-712, 2004.

  37. Naviaux RK, ed. Mitochondrial Medicine—Developing the Scientific Foundations for the Medical Management of Mitochondrial Disease, Mitochondrion. 4:349-824, Elsevier, Oxford, UK, 2004.

  38. Naviaux RK. Developing a systematic approach to the diagnosis and classification of mitochondrial disease. Mitochondrion. 4:351-361, 2004.

  39. Phillips PS, Phillips CT, Sullivan MJ, Naviaux RK, Haas RH. Statin myotoxicity is associated with changes in the cardiopulmonary function. Atherosclerosis. 177:183-188, 2004.

  40. Barshop BA, Naviaux RK, McGowan KA et al. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 83:138-149, 2004.

  41. Gourley PL, Naviaux RK. Optical phenotyping of human mitochondria in a biocavity laser. IEEE J. Selected Topics Quantum Electronics. 11:818-826, 2005.

  42. Naviaux RK, Nguyen KV. POLG mutations associated with Alpers syndrome and mitochondrial DNA depletion. Ann Neurol. 58:491, 2005.

  43. Petit C, Pietri-Rouxel F, Lesne A, Naviaux RK. Oxygen consumption by cultured human cells is impaired by a nucleoside analogue cocktail that inhibits mitochondrial DNA synthesis. Mitochondrion. 5:154-161, 2005.

  44. Chan SS, Longley MJ, Naviaux RK, Copeland WC. Monoallelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. DNA Repair (Amst). 4:1381-1389, 2005.

  45. Gourley PL, Hendricks JK, McDonald AE, Naviaux RK. Mitochon­ drial correlation microscopy and nanolaser spectroscopy—new tools for biophotonic detection of cancer in single cells. Technol Cancer Res Treat. 4:585-592, 2005.

  46. Nguyen KV, Ostergaard E, Ravn SH, Balsley T, Danielsen ER, Vardag A, McKiernan PJ, Gray G, Naviaux RK. POLG mutations in Alpers syndrome. Neurology. 65:1493-1495, 2005.

  47. Naviaux RK, Good B, McPherson JD et al. Sand DNA—a genetic library of life at the water’s edge. Marine Ecology-Progress Series. 301:9-22, 2005.

  48. Gourley PL, Hendricks JK, McDonald AE, Naviaux RK. Ultrafast nanolaser flow device for detecting cancer in single cells. J Biomedical Microdevices. 7(4):331-339, 2005.

  49. Nguyen KV, Sharief FS, Chan SSL, Copeland WC, Naviaux RK. Molecular diagnosis of Alpers syndrome. J Hepatology. 45(1):108-116, 2006.

  50. Gourley PF, Hendricks JK, McDonald AE, Copeland RG, Yaffe MP, Naviaux RK. Biocavity Laser Spectroscopy of Genetically-altered Yeast Cells and Isolated Yeast Mitochondria. Proc. of  SPIE Imaging, Spectroscopy, and Manipulation of Molecules, Organelles and Cells. 2006.

  51. Jiang Y, Hall TA, Hofstadler SA, Naviaux RK. Mitochondrial DNA mutation detection by electrospray mass spectrometry. Clin Chem. 53:195-203, 2007.

  52. Verma M, Naviaux RK, Tanaka M, Kumar D, Franceschi D, and Singh KK. Mitochondrial DNA and Cancer Epidemiology. Cancer Res 67:437-439, 2007.

  53. Ashley N, Adams S, Slama A, Zeviani M, Suomalainen A, Andreu AL, Naviaux RK, Poulton J. Defects in Maintenance of Mitochondrial DNA are Associated with Intramitochondrial Nucleotide Imbalances. Human Molecular Genetics 16:1400-1411, 2007.

  54. Kok Seong Lim, Robert K. Naviaux, Richard H. Haas. Quantitative DNA Mutation Analysis by DHPLC. Clin Chem 53:1046-1052, 2007.

  55. Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans R. ERRg Directs and Maintains the Transition to Oxidative Metabolism in the Post-Natal Heart. Cell Metabolism 6:13-24, 2007.

  56. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Yaffe MP, Naviaux RK. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: A rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Optics 12:1-14, 2007.

  57. Lim KS, Naviaux RK, Haas RH. Pitfalls in the DHPLC analysis of mitochondrial DNA mutations. J Molec Diag 10(1):102-108, 2007.

  58. Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darini N, Wong L-J, Cohen BH, Naviaux RK. The in-depth evaluation of suspected mitochondrial disease: The Mitochondrial Medicine Society’s Committee on Diagnosis. Molec Gen Metab 94(1):16-37, 2008.

  59. Gourley PL, Sasaki DY, Naviaux RK. Nanolaser spectroscopy for studying novel biomaterials. Proceedings of the International Society for Optical Engineering (SPIE). 6859:1-10, 2008.

  60. Wong L-J, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, Basinger AA, Burton BK, Swoboda K, Gilbert DL, Vanderver A, Saneto RP, Maranda B, Arnold G, Abdenur JE, Waters PJ, Copeland WC. Molecular and clinical genetics of mitochondrial disease due to POLG mutations. Hum Mut 2008, Epub ahead of print.

  61. Saitoh A, Haas RH, Naviaux RK, Salva NG, Wong JK, Spector SA. Impact of nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA and RNA in human skeletal muscle cells. Antimicrobial Agents Chemo 52:2825-2830, 2008.

  62. Naviaux RK. Mitochondrial control of epigenetics. Cancer Biology and Therapy 7:1191-1193, 2008.

  63. Sachadyn P, Zhang X-M, Clark LD, Naviaux RK, Heber-Katz E. Naturally-Occurring Mitochondrial DNA Heteroplasmy in the MRL Mouse. Mitochondrion. 2008, Epub ahead of print.

  64. Naviaux RK, Le TP, Bedelbaeva K, Leferovich J, Gourevitch D, Sachadyn P, Zhang X-M, Clark L, Heber-Katz E. Retained features of embryonic metabolism in the adult MRL Mouse. Molecular Genetics and Metabolism 2009;96:133-144, PMID: 19131261

  65. Chan SS, Naviaux RK, Basinger AA, Casas KA, Copeland WC. De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion. 2009.

  66. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15;389(2):157-164.

  67. Lim KS, Naviaux RK, Haas RH. Determination of DNA Mutation Load in Human Tissues Using Denaturing HPLC-Based Heteroduplex Analysis. Methods Mol Biol. 2009;554:287-299.

  68. Angly FE, Willner D, Prieto-Davó A, Schmieder R, Vega-Thurber R, Antonopoulos DA, Barott K, Cottrell MT, Desnues C, Dinsdale EA, Furlan M, Haynes M, Henn MR, Hu Y, Kirchman DL, McDole T, McPherson JD, Meyer F, Miller RM, Mundt E, Naviaux RK, Rodriguez-Brito B, Stevens R, Wegley L, Zhang L, Zhu B, Rohwer F. The GAAS Metagenomic Tool and its Application to the Estimation of Viral and Microbial Average Genome Size in Four Biomes. PLoS Comput Biol 2009; 5(12):e1000593 (PMID: 20011103)

  69. Saneto RP, Lee IC, Koenig MK, Bao X, Weng SW, Naviaux RK, Wong LJ. POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. Seizure 2010; 19(3):140-146, PMID:20138553.

  70. Cohen BC, Naviaux RK. The Clinical Diagnosis of POLG Disease and other Mitochondrial DNA Depletion Disorders. Methods Molec Biol 2010

  71. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Role of reactive oxygen species in hyper-adrenergic hypertension: Biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin A (Chga) gene. Circulation 3:414-425, 2010.

  72. Saneto R, Naviaux RK. Polymerase Gamma Disease Through the Ages. Developmental Disabilities Research Rev 2010;16:163-174.

  73. Nguyen KV, Naviaux RK, Patra S, Barshop BA, Nyhan WL. Novel mutation in the human MCCA and MCCB gene causing methylcrontonylglycinuria. Mol Genet Metab 102:218-221, 2011 (PMID 21071250)

  74. Du A, Naviaux RK, Le T, Xu C, Sommer SS, Haas RH. Fibroblast immunodiagnosis of cytochrome oxidase (COX) deficiency in mitochondrial disease. Mitochondrion 11(3):430-6, 2011.

  75. Nguyen KV, Naviaux RK, Paik KK, Nyhan WL. Novel Mutations in the Human HPRT Gene. Nucleosides, Nucleotides and Nucleic Acids, 30(6):440-445, 2011.

  76. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkin G, Murphy A, Naviaux RK, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: Effects of epicatechin rich cocoa. CTS Clinical and Transl Sci, 2012;5:43-47. PMID: 22376256

  77. Frye RE, Naviaux RK. Autistic disorder with complex IV overactivity: A new mitochondrial syndrome. J Ped Neurol 9:1-8, 2011.

  78. Smith M, Flodman PL, Gargus JJ, Simon MT, Verrell K, Haas RH, Reiner GE, Naviaux RK, Osann K, Spence A, Wallace DC. Mitochondrial and ion channel gene alterations in autism. BBA, 1817(10):1796-802. 2012 PMID: 22538295

  79. Naviaux RK. Oxidative shielding or oxidative stress? J Pharmacol Exp Ther, 342(3):608-18, 2012. PMID: 22700427

  80. Nguyen KV, Naviaux RK, Paik KK, Nyhan WL. Lesch-Nyhan Syndrome: mRNA expression of HPRT in patients with enzyme proven deficiency of HPRT and normal HPRT coding region of the DNA. Mol Genet Metab. 2012 Aug;106(4):498-501. PMID: 22766437

  81. Nguyen KV, Naviaux RK, Paik KK, Nakayama T, Nyhan WL. Lesch-Nyhan variant syndrome: real-time rt-PCR for mRNA quantification in variable presentation in three affected family members. Nucleosides Nucleotides Nucleic Acids. 2012 Aug;31(8):616-29. PMID: 22908952

  82. Naviaux RK. Mitochondria and Autism Spectrum Disorders, in The Neuroscience of Autism Spectrum Disorders. Buxbaum J, Hof P (eds). Elsevier, San Diego, 2013.

  83. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell SB. Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model. PloS one 8, e57380 (2013).

  84. Sharma K, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Ix JH, Karl B, Sharma S, You Y, Wang L, Diamond-Stanic M, RamachandraRao S, Lindenmeyer MT, Forslblom C, Ideker T, Cohen CD, Groop P-H, Barshop BA, Naviaux RK. Urine Metabolomics Reveals a Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease. JASN 2013;24:1901-1912.

  85. Saneto RP, Cohen BH, Copeland WC. Naviaux RK. Alpers-Huttenlocher syndrome. Pediatr Neruol 2013;48:167-178.

  86. Dugan LL, You Y-H, Ali SS, DeCleves A-E, Okada S, Shekhtman G, Le TP, Wang L, Xu M, Paik KK, Naviaux RK, Sharma K. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. JCI 2013;123:4888-4899.

  87. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Crawford A, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki M, Al-Baradie R, Faqeih E, Spencer E, Rosti RO, Scot E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. AMPD2 Regulates GTP Synthesis and is Mutated in Potentially-Treatable Neurodegenerative Brainstem Disorder. Cell 2013;154:505-517.

  88. Naviaux RK. Metabolic Features of the Cell Danger Response. Mitochondrion, 2014;16:7-17.

  89. Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GH, Hamilton G. Preliminary Report: Assessing Bioenergetic Compromise in Autism with 31P-MRS. J Child Neurol 2014;85(3):611-623.

  90. Decleves A-E, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K. Regulation of lipid accumulation by AMPK in high fat diet-induced kidney injury. Kidney International 2013; 85:611-623.

  91. McCloskey D, Gangoiti JA, King ZA, Naviaux RK, Barshop BA, Palsson BO, Feist AM. A model-driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K-12 MG1655 that is biochemically and thermodynamically consistent. Biotechnology and Bioengineering 111:803-815, 2013.

  92. McCloskey D, Utrilla J, Naviaux RK, Palsson BO, Feist AM. Fast Swinnex Filtration (FSF): A fast and robust sampling and extraction method suitable for metabolomics analysis of cultures grown in complex media. Metabolomics 2014, in press.

  93. Naviaux JC, Schucbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Translational Psychiatry 2014.

  94. RamachandraRao SP, Matthias MA, Mondrogon CK, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM and Mauri P (2015) Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats, PLoS Negl Trop Dis 9, e0003640.

  95. Wall CE, Whyte J, Suh JM, Fan W, Collins B, Liddle C, Yu RT, Atkins AR, Naviaux JC, Li K, Bright AT, Alaynick WA, Downes M, Naviaux RK and Evans RM (2015) High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice, Proceedings of the National Academy of Sciences of the United States of America 112, 8714-8719.

  96. Naviaux RK. Childhood Alpers-Huttenlocher Syndrome, in Saneto RP, Parikh S, and Cohen BH (eds), Mitochondrial Disease: Comprehensive Review and Case Discussions.  Elsevier, New York, NY, 2015.

  97. S.P. RamachandraRao, M.A. Matthias, C.K. Mondrogon, E. Aghania, C. Park, C. Kong, M. Ishaya, A. Madrigal, J. Horng, R. Khoshaba, A. Bounkhoun, F. Basilico, A. De Palma, A.M. Agresta, L. Awdishu, R.K. Naviaux, J.M. Vinetz, P. Mauri, Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats, PLoS Negl Trop Dis, 9 (2015) e0003640.

  98. C.E. Wall, J. Whyte, J.M. Suh, W. Fan, B. Collins, C. Liddle, R.T. Yu, A.R. Atkins, J.C. Naviaux, K. Li, A.T. Bright, W.A. Alaynick, M. Downes, R.K. Naviaux, R.M. Evans, High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice, Proceedings of the National Academy of Sciences of the United States of America, 112 (2015) 8714-8719.

  99. J.C. Naviaux, L. Wang, K. Li, A.T. Bright, W.A. Alaynick, K.R. Williams, S.B. Powell, R.K. Naviaux, Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model, Molecular autism, 6 (2015) 1.

  100. R.K. Naviaux, J.C. Naviaux, K. Li, A.T. Bright, W.A. Alaynick, L. Wang, A. Baxter, N. Nathan, W. Anderson, E. Gordon, Metabolic features of chronic fatigue syndrome, Proceedings of the National Academy of Sciences of the United States of America, DOI 10.1073/pnas.1607571113(2016).

  101. L.A. Pan, P. Martin, T. Zimmer, A.M. Segreti, S. Kassiff, B.W. McKain, C.A. Baca, M. Rengasamy, K. Hyland, N. Walano, R. Steinfeld, M. Hughes, S.K. Dobrowolski, M. Pasquino, R. Diler, J. Perel, D.N. Finegold, D.G. Peters, R.K. Naviaux, D.A. Brent, J. Vockley, Neurometabolic Disorders: Potentially Treatable Abnormalities in Patients With Treatment-Refractory Depression and Suicidal Behavior, The American journal of psychiatry, DOI 10.1176/appi.ajp.2016.15111500(2016).

  102. K.V. Nguyen, R.K. Naviaux, W.L. Nyhan, Human HPRT1 Gene and the Lesch-Nyhan Disease: Substitution of Alanine for Glycine and Inversely in the HGprt Enzyme Protein, Nucleosides, nucleotides & nucleic acids, DOI 10.1080/15257770.2016.1231319(2017) 1-7.

  103. P.S. Garimella, K. Li, J.C. Naviaux, M.G. Shlipak, J.A. Abdelmalek, E. Castro, E.V. Capparelli, R.K. Naviaux, J.H. Ix, Utility of Spot Urine Specimens to Assess Tubular Secretion, Am J Kidney Dis, DOI 10.1053/j.ajkd.2016.12.016(2017).

  104. Batova, D. Altomare, K.E. Creek, R.K. Naviaux, L. Wang, K. Li, E. Green, R. Williams, J.C. Naviaux, M. Diccianni, A.L. Yu, Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma, PloS one, 12 (2017) e0172632.

  105. K.K. Higa, A. Grim, M.E. Kamenski, J. van Enkhuizen, X. Zhou, K. Li, J.C. Naviaux, L. Wang, R.K. Naviaux, M.A. Geyer, A. Markou, J.W. Young, Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice, Psychopharmacology, DOI 10.1007/s00213-017-4572-2(2017).

  106. K.V. Nguyen, S. Silva, M. Troncoso, R.K. Naviaux, W.L. Nyhan, Lesch-Nyhan disease in two families from Chiloe Island with mutations in the HPRT1 gene, Nucleosides, nucleotides & nucleic acids, DOI 10.1080/15257770.2017.1315434(2017) 1-11.

  107. R.K. Naviaux, B. Curtis, K. Li, J.C. Naviaux, A.T. Bright, G.E. Reiner, M. Westerfield, S. Goh, W.A. Alaynick, L. Wang, E.V. Capparelli, C. Adams, J. Sun, S. Jain, F. He, D.A. Arellano, L.E. Mash, L. Chukoskie, A. Lincoln, J. Townsend, Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial, Ann Clin Transl Neurol, 4 (2017) 491-505.

  108. K.V. Nguyen, R.K. Naviaux, W.L. Nyhan, Novel mutation in the human HPRT1 gene and the Lesch-Nyhan disease, Nucleosides, nucleotides & nucleic acids, 36 (2017) 704-711.

  109. K.V. Nguyen, S. Silva, M. Troncoso, R.K. Naviaux, W.L. Nyhan, Lesch-Nyhan disease in two families from Chiloe Island with mutations in the HPRT1 gene, Nucleosides, nucleotides & nucleic acids, 36 (2017) 452-462.

  110. J.B. Adams, T. Audhya, E. Geis, E. Gehn, V. Fimbres, E.L. Pollard, J. Mitchell, J. Ingram, R. Hellmers, D. Laake, J.S. Matthews, K. Li, J.C. Naviaux, R.K. Naviaux, R.L. Adams, D.M. Coleman, D.W. Quig, Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial, Nutrients, 10 (2018).

  111. R.K. Naviaux, Antipurinergic therapy for autism-An in-depth review, Mitochondrion, DOI 10.1016/j.mito.2017.12.007(2017).

  112. Haas, R.H. & Naviaux, R.K. A brief history of the Mitochondrial Medicine Society—The first 20 years, 1998-2018. Mitochondrial and Metabolic Medicine 1, 1-7 (2019).

  113. Awdishu, L., et al. Identification of Maltase Glucoamylase as a Biomarker of Acute Kidney Injury in Patients with Cirrhosis. Crit Care Res Pract 2019, 5912804 (2019).

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